Advances in the Study of Bionic Mineralized Collagen, PLGA, Magnesium Ionomer Materials, and Their Composite Scaffolds for Bone Defect Treatment

The healing of bone defects after a fracture remains key issue to be addressed. Globally, more than 20 million patients experience annually. Among all artificial repair materials that can aid healing, implantable scaffolds made from mineralized collagen (MC) base have the strongest bionic properties. MC/PLGA scaffold, created by adding Poly (lactic-co-glycolic acid) copolymer (PLGA) and magnesium metal MC substrate, plays powerful role in promoting because, on one hand, it has good biocompatibility similar MC; other addition PLGA provides scaffold with an interconnected porous structure, allows perform anti-inflammatory, osteogenic, angiogenic activities. Using latest 3D printing technology for fabrication, is possible model advance according requirement produce therapeutic suitable various bone-defect shapes less time effort, which promote tissue regeneration maximum extent. This study reviews material selection technical preparation scaffolds, progress their research defect treatment.